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Molly A. Guscott

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Open access Oct 2026

Chromosomal instability drives continual flux in cancer genomes

Tumour genomes are grossly altered at the chromosome scale in most cancer types. Copy number alterations (CNAs), entire chromosome gains and losses, and whole genome duplication (WGD) are generated by Chromosomal instability (CIN) and shaped by evolutionary selection. Cancer genomics studies have widely demonstrated th...

Molly A. Guscott, A. Lumeau, Annie D. Gallagher et al. · 0 citations

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