Open access
Aug 2026
Morphogen-guided neocortical organoids with anteroposterior areal identity
Summary The human neocortex exhibits characteristic regional patterning (arealization) critical for higher-order cognitive function. Disrupted arealization is implicated in neurodevelopmental disorders (NDDs), but current neocortical organoid models largely fail to recapitulate this patterning, limiting mechanistic und...
Yuan-Chen Tsai, Hajime Ozaki, Axel A. Almet et al.
· Cell Stem Cell · 1 citation