Monisha Prasad

TEAD as a druggable target in Hippo signaling: Structure-based discovery of small-molecule inhibitors.

The Hippo signaling pathway is a well-conserved signaling pathway responsible for regulating tissue homeostasis, organ size, proliferation, apoptosis, and stem cell renewal. The dysregulation of the Hippo signaling pathway, specifically abnormal activation of the YAP/TAZ-TEAD transcriptional complex, has become a key p...