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Author

Morgan Sheng

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Open access Aug 2026

Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency in vitro but has limited impact in vivo

Improved capsids for in vitro manipulation of microglia are developed and viral genome design, not capsid identity, is established as the principal determinant of efficient in vivo microglial targeting.

Saša Jereb, Lia R. D’Alessandro, Nader Morshed et al. · 0 citations
Open access Aug 2026

Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

This work provides a mechanistic link between high-penetrance SETD1A variants and region-specific brain dysfunction, establishing a framework for connecting rare loss-of-function variation in chromatin regulators to multidimensional neuropsychiatric phenotypes.

Yiqiong Liu, Guoguang Xie, Shan Jiang et al. · 0 citations

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