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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Moritz Thran

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Open access Oct 2026

Structural basis of eIF4E recognition of synthetic mRNA 5′ cap analogues links cap architecture to affinity and biological activity

Eukaryotic mRNAs carry a 5′-terminal 7-methylguanosine (m7G) cap that is recognized by multiple cellular proteins and is essential for mRNA self-discrimination, stability, and translation. The eukaryotic translation initiation factor 4E (eIF4E) binds the 5′ cap and promotes recruitment of mRNAs to the ribosomal transla...

Sabine Schneider, Sarah Moreno, Moritz Thran et al. · 0 citations

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