Moustafa T. Gabr

ClinOracle: Hierarchical AI Prediction of Target Binding and Patient-Derived Functional Activity Across Diverse Therapeutic Targets

A small molecule inhibitor of CD28 costimulation restrains pathogenic T-cell responses in inflammatory bowel disease

Small Molecule Modulation of NOS1AP for Molecularly Targeted Glioblastoma Therapy

This study identifies an initial NOS1AP-binding compound and shows that it can alter a NOS1AP-containing protein complex in living cells, and provides a foundation for optimizing NOS1AP-directed compounds and developing delivery systems to enhance brain penetration, tumor-selective accumulation, and therapeutic exposur...

AI-guided discovery of a brain-penetrant LILRB4 inhibitor active in microglial and 5xFAD models of Alzheimer's disease.

In human induced pluripotent stem cell-derived microglia, compound 4 reduced SHP1/2 phosphorylation, attenuated NF-κB activation and IL-1β secretion, and restored Aβ uptake without compromising cell viability, and the compound exhibited oral bioavailability and brain penetration.

CAR T cell therapy beyond cancer: current status, challenges and future prospects

This review highlights how CAR-based strategies can be adapted across diverse disease settings by redirecting engineered immune responses toward disease-sustaining cellular compartments and position programmable cellular immunotherapy as a broadly adaptable platform for eliminating persistent pathological cells, remode...