Open access
Aug 2026
A programmable lipid-triggered allosteric site modulates LC3 LIR receptor binding activity
It is uncovered that membrane binding triggers a major conformational transition in LC3, exposing functional pockets that are occluded in its cytosolic form and can be engineered to precisely tune LC3-LIR interactions, offering a new strategy to regulate selective autophagy.
Deepanshi Gahlot, Jesu Castin, S. Mathur et al.
· Nature Communications · 0 citations