Author

Mu-Lin Li

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Open access Sep 2026

HOTAIR Promotes Prostate Cancer Progression by facilitating CDK9-Pol II Association and Transcriptional Elongation

Previous research has predominantly focused on the regulatory role of lncRNA HOTAIR in gene silencing by interacting with the Polycomb repressive complex 2 (PRC2), but its direct role as a transcriptional activator remains less well characterized. Here, our study reveals a novel regulatory mechanism of HOTAIR, which fa...

Yu-Yang Qian, Bo Wang, Guang-Song Su et al. · International Journal on Bio... · 0 citations

Open access Sep 2026

Androgen receptor condensates drive gastric cancer through SWI/SNF-mediated chromatin remodeling and create a therapeutic vulnerability

Gastric cancer (GC) remains a leading cause of cancer mortality, with epidemiological patterns indicative of androgen signaling involvement. We establish androgen receptor (AR) as a pivotal oncogenic factor in GC and provide preclinical validation for its therapeutic targeting. AR expression was significantly eleva...

Hua-Huan Liu, Yan-Xin Yao, Xiang-Nan Zhang et al. · Cell Death & Disease · 0 citations