Mudasir Alvi

Integrating deep learning model for precision design of MERS antibodies with augmented affinity against SARS-CoV-2.

The rapid emergence of SARS-CoV-2 has renewed interest in cross-reactive antibody therapeutics targeting conserved epitopes across divergent coronaviruses. Building on our deep-learning driven protein engineering pipeline, we sought to redirect experimentally validated MERS-CoV antibodies toward the SARS-CoV-2 receptor...