Development and Optimization of a Ketoprofen–Lidocaine Dual Drug Transdermal Patch for Enhanced Skin Permeation and Sustained Analgesic Activity
The present study aimed to develop and evaluate a dual drug transdermal patch containing ketoprofen and lidocaine for sustained drug delivery. Transdermal patches were prepared using the solvent casting technique with hydroxypropyl methylcellulose (HPMC) and ethyl cellulose as matrix-forming polymers, PEG 400 as a plas...