Muhammad Tahir Naseem

Beyond copy number: circulating cell-free mitochondrial DNA Fragmentomics and structural states in liquid biopsy.

Circulating cell-free mitochondrial DNA (cf-mtDNA) is commonly treated as a concentration-based biomarker, yet the measured signal is a composite of biologically distinct molecular states that are differentially affected by blood collection, platelet activation, centrifugation, storage, extraction, amplification, and s...