Spatial transcriptomics enables high-throughput gene expression profiling while preserving spatial information, offering valuable insights into tissue architecture and cellular organization. Methods that achieve single-cell or subcellular spatial resolution typically rely on predefined gene panels, which limits genome-...
A. Abir, Muhtasim Noor Alif, Wei Zhang· bioRxiv· 0 citations
Computational cellular deconvolution enables researchers to estimate the proportions of distinct cell types in bulk RNA-sequencing (RNA-seq) samples using single-cell RNA-seq (scRNA-seq) as a reference. This offers a scalable and cost-effective alternative to physical cell separation. Despite recent advancements in cel...
Ayesha A. Malik, Muhtasim Noor Alif, Ayla Bratton et al.· Computational biology and ch...· 0 citations
SPIDER is introduced, a semi-supervised framework that leverages independently generated, annotated single-cell RNA-seq (scRNA-seq) references to guide ST denoising, providing a generalizable solution for robust ST data denoising.