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Mythreyi Jannu

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Open access Aug 2026

Circulating methylated promoters of HK2 and EGFR as biomarkers in the early detection of cancer

Introduction Aberrant methylation of promoter DNA regions is a well-known epigenetic hallmark of cancer. Previous studies on tumorigenic mouse models revealed that abnormal methylation in the promoter regions of selected genes occurs during the early stages of tumorigenesis. To explore further changes in the blood circ...

Mythreyi Jannu, Ramesh Ummanni, Rajeswari Jinka · 0 citations
Open access Jul 2026

Identification of Novel Lead Molecules against Hexokinase-2 using Structure-based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations

This study considered HK2 as a promising target for anticancer strategies by screening a large in-house library of 1.28 million compounds and obtained several lead molecules that exhibited favourable XPG and MM/GBSA scores, steady binding trajectories and sustained interactions.

Mythreyi Jannu, B. Krishnan, U. Amineni et al. · 0 citations

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