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N. Bergum

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Open access Sep 2026

The impact of α-synuclein overexpression on nigrostriatal transmission

Accumulation of wild-type α-synuclein in dopamine neurons of the Substantia Nigra pars compacta (SNc) is a pathological hallmark of Parkinson’s disease (PD), which commonly precedes neurodegeneration. Yet how α-synuclein accumulation affects nigrostriatal neurotransmission early in the progression of PD remains poorly...

N. Bergum, Andrew G. Yee, Robert H. Edwards et al. · 0 citations

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