Open access
Oct 2026
A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration
Spinella et al. linked a Crohn’s disease risk allele regulating SKAP2 expression to T lymphocyte function. SKAP2 enhances cell adhesion while suppressing migration. Sustained TCR signaling triggers its proteolytic cleavage to enable migration. Overall, genetic alteration of SKAP2 levels drives T cell dysfunction and pr...
Mara Cetty Spinella, Francesco Gualdrini, Cristina Leoni et al.
· Journal of Experimental Medi... · 0 citations