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A narrative review summarizes molecular classifications and candidate biomarkers associated with BCG response and assesses their potential clinical utility, based on a focused search of PubMed, Scopus, and Web of Science through July 2026, supplemented by ClinicalTrials.gov.
Assessment of the role of germline CHEK2 variants in the development of different cancer types confirmed that CHEK2 c.470T>C is the most common variant in the patient group, and the contribution of this variant to hereditary cancer risk in the Russian population is modest.
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