An immune-metabolic transcriptomic balance stratifies acute myeloid leukemia and reveals distinct immunological and signaling dependencies.
Acute myeloid leukemia (AML) remains genetically and clinically heterogeneous, and current cytogenetic risk categories do not fully capture biologic diversity or therapeutic vulnerability. We investigated whether a simple THBS1/VEGFA transcriptional ratio could define molecularly distinct AML subsets with prognostic an...