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Author

N. El-Metwaly

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2 papers indexed here

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Open access Nov 2026

Discovery of new indole-thiazolidin-4-one hybrid derivatives as anticancer agents: Synthesis, biological evaluation, molecular docking toward VEGFR-2 , and DFT studies.

A new series of indole–thiazolidin-4-one hybrid derivatives ( IN-1–IN-5 ) was designed and synthesized as potential anticancer agents by integrating two biologically privileged scaffolds into a single molecular framework. The compounds were characterized using standard spectroscopic techniques and evaluated for the...

Z. H. Alnakhli, Shorog Alotaiby, H. Alshareef et al. · 0 citations
Open access Aug 2026

Mechanistic insights into antioxidant and antibacterial effects of indole-pyrazole-carbohydrazide hybrids through density functional theory, docking, and molecular dynamics studies

A new series of indole-pyrazole-carbohydrazide derivatives ( IH-1-IH-5 ) was synthesized through acid-catalyzed condensation of 1H-indole-5-carbaldehyde with substituted pyrazole-5-carbohydrazides, aiming to develop multifunctional antioxidants and antibacterials. In2,2′-diphenyl-1-picrylhydrazyl (DPPH) assays, ele...

Shorog M. Alotaiby, Samar J. Almehmadi, Nuha M. Halawani et al. · 0 citations

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