Development and Optimisation Using D-Optimal Design of Dual-Functionalized Hyaluronic Acid-Chitosan-Coated Mesoporous Silica Nanoparticles for Repurposed Propranolol Delivery in Breast Cancer: A Proof-of-Concept Study.
Drug repurposing combined with nanocarrier systems can accelerate cancer therapy development while reducing the time and cost of conventional drug discovery. We developed and optimised hyaluronic acid (HA)-chitosan (CH)-coated mesoporous silica nanoparticles (HA-CH-Prop-MSNPs) for delivery of the repurposed β-blocker p...