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N. Empadinhas

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Open access Sep 2026

Mucosal microbiota and intraepithelial lymphocyte remodeling link maternal immune activation to neuroimmune outcomes in female and male offspring

Background Maternal immune activation (MIA) is associated with increased risk for neurodevelopmental disorders, including schizophrenia and autism spectrum disorder, yet its long-term impact on intestinal immune-microbial programming remains incompletely understood. Here, we investigated whether lipopolysaccharide (LPS...

A. R. Pereira-Santos, Soraia Jesus-Faria, Emanuel Candeias et al. · 0 citations
Open access Jul 2026

A cryptic aromatic binding pocket in the highly thermostable GpgS from Mycobacterium hassiacum hints at MGLP pathway crosstalk

The findings establish M. hassiacum as a valuable model for structural enzymology in mycobacteria and highlight GpgS as a potential drug target, opening new avenues for the development of inhibitors targeting this key, potentially pleiotropic enzyme.

Daniela Nunes-Costa, Alexandra Silva, Susana Alarico et al. · 0 citations

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