Open access
Aug 2026
Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders
An input-specific translatome screen is designed to identify regulators of experience-dependent PV IN plasticity genes (XPGs) in the CA3/CA2 subregion of adult hippocampus and shows that experience-dependent PV IN plasticity is a convergent mechanism for NDD risk genes that can be re-instated in adulthood to reverse developmental deficits in circuitry, network excitability and cognition.
Yu-Tzu Shih, J. Alipio, Z. Klaft et al.
· Nature · 2 citations