Author

N. Harnett

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Open access Oct 2026

Distinct Multimodal Brain Profiles Bridging Age of First Alcohol Use and Subsequent Substance Use in Young Adults

Age of first alcohol use is associated with alterations in brain development and an increased risk of problematic substance use later in life. However, it remains unclear if neurobiological alterations associated with first-use age are present in young adulthood and how these alterations may be associated with differen...

K. Hannon, N. Harnett, Y. Cheng et al. · medRxiv · 0 citations

Open access Sep 2026

Epigenetic age acceleration is associated with brain connectivity changes and the risk of major depression after trauma

Background: Major depressive disorder (MDD) is associated with brain dysfunction and age-related diseases. Epigenetic clocks based on DNA methylation patterns estimate biological aging and aim to predict morbidity and mortality. Although MDD has been linked to epigenetic age acceleration (EAA) cross-sectionally, it is...

A. Navarro-Flores, Hazel Milla, S. Linnstaedt et al. · medRxiv · 0 citations

Open access Jul 2026

Ancestry-Calibrated Polygenic Risk Scores Predict PTSD Trajectories in Recent Trauma Survivors and Interact with Neighborhood Resources

Objective: Polygenic risk scores (PRS) for posttraumatic stress disorder (PTSD) often account for a low amount of variance. Ancestry-related differences in PRS scale and variance limit cross-group comparisons. This methodological challenge further complicates gene-by-environment (GxE) analyses, given that socioenvironm...

E. Webb, Aarti Jajoo, Vijetha Balakundi et al. · medRxiv · 0 citations