Endocrine and Molecular Mechanisms of Oocyte Aging: From Gonadotropin Signaling to Metabolic and Microenvironmental Dysfunction
Ovarian aging and oocyte aging are closely interconnected but distinct components of reproductive aging. Whereas ovarian aging encompasses progressive follicular depletion and changes in ovarian endocrine and somatic-cell function, oocyte aging refers more specifically to the age-associated deterioration in the molecul...