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Author

N. Kuznetsov

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Oct 2026

Substrate specificity and activity of extremotolerant tardigrade AP-endonuclease 1.

Tardigrades are microinvertebrates known for their extreme resilience to ionizing radiation, desiccation, and other environmental stresses. This tolerance is partly attributed to efficient DNA repair mechanisms. Here, we biochemically characterized the apurinic/apyrimidinic endonuclease 1 from Hypsibius exemplaris (hex...

Anastasia M. Yakovleva, Elena S. Mikushina, M. Meschaninova et al. · 0 citations
Sep 2026

Pre-steady-state kinetic analysis of dNTP and DNA binding by human terminal deoxynucleotidyl transferase.

Investigation of conformational dynamics enzyme-substrate complexes using wild type enzyme and set of mutant forms of human TdT provides link between function of active site amino acids and kinetics of molecular events within individual stages of the catalytic cycle.

Svetlana S. Senchurova, A. Kuznetsova, N. Kuznetsov · 0 citations

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