The known universe of protein families represents only a small fraction of nature’s molecular diversity. From 40.3 billion sequences across 40,446 metagenomes, 9,540 metatranscriptomes, and 539 million proteins from 167,415 reference genomes, we identified 608,258 previously uncharacterized protein families with ≥100 m...
Eleni Aplakidou, Fotis A. Baltoumas, Maria N. Chasapi et al.· bioRxiv· 0 citations
Microbial genomes encode non-coding RNAs (ncRNAs) and nucleic-acid-interacting proteins essential to biology and biotechnology. However, discovery of these systems remains protein-centric and based on similarity to known sequences. Here, we introduce Minerva, a framework for coevolutionary mining that uses genome langu...
David B. Li, G. Brixi, Alexandra S. Kim et al.· bioRxiv· 1 citation
The rise of antibiotic-resistant bacteria demands alternative therapeutic strategies, with bacteriophage (phage) therapy and phage-derived enzybiotics emerging as promising approaches. However, identifying candidate phages against specific pathogens has historically been a bottleneck due to the need for cultivation met...
Mateus B. Fiamenghi, N. Kyrpides· bioRxiv· 0 citations
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