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Open access Oct 2026

Distinct profiles of white matter diffusivity in obesity and bipolar disorders: An ENIGMA bipolar disorders study in 2166 individuals

Abstract Background Bipolar disorders (BD) are associated with a wide range of brain white matter abnormalities, but results vary across studies. This heterogeneity likely relates to effects of additional clinical/diagnostic variables, including medications and obesity, on white matter in BD. In this mega-analysis, we...

Lorielle M. F. Dietze, Sean R. McWhinney, P. Favre et al. · 0 citations
Open access Sep 2026

Cognitive Reserve as a Stratification Factor for Cognitive Impairment and Disease Progression in Major Depressive Disorder.

The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.

M. Gruber, Henrike Renaud, M. Mauritz et al. · 0 citations
Open access Aug 2026

The timeline of brain aging in major depression: A prospective study from before first-onset to established illness

Major depressive disorder (MDD) has been associated with accelerated structural brain aging, yet whether this reflects a pre-existing neurobiological vulnerability, a dynamic acute state effect, or an accumulating biological residual remains unresolved. Across two longitudinal cohorts (N=3220), including a unique sampl...

M. Konowski, A. Kraus, J. Goltermann et al. · 0 citations

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