Author

N. P. Bona

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Open access Sep 2026

BHT-derived thiazolidin-4-ones: synthesis, radical scavenging activity, and in silico evaluation.

Butylated hydroxytoluene (BHT) is a recognized antioxidant, while thiazolidin-4-ones are versatile scaffolds for bioactive molecule design. Here, BHT-functionalized thiazolidin-4-ones were synthesized with systematic variation at the N-3 position. Multicomponent synthetic strategies afforded thiazolidin-4-ones (4), a p...

M. G. Victor, B. C. Moreira, Cinara Teiroba de Ávila et al. · RSC Medicinal Chemistry · 0 citations

Open access Sep 2026

Ellagic acid regulates astrocytic responses under inflammatory conditions in primary astrocyte cultures: effects on oxidative stress, inflammatory cytokines, and glycogen synthase kinase-3β

Neuroinflammation involves the activation of glial cells, particularly astrocytes, and microglia, in response to pathological stimuli. Astrocyte activation is characterized by increased pro-inflammatory cytokines and oxidative stress. Given their role in neuroinflammation, targeting astrocytic mechanisms presents poten...

T. M. da Rosa, L. M. da Silveira, N. P. Bona et al. · Molecular Biology Reports · 0 citations