Biofluid proteins are promising transdiagnostic markers for delineating disease heterogeneity in psychosis. This study examined proteomic profiles in a transdiagnostic early psychosis sample to test the hypothesis that psychosis is associated with proteomic signatures of premature aging. We analyzed proteomic data from...
J. Seitz-Holland, M. Haaf, A. Mendes-Silva et al.· Brain, behavior, and immunit...· 0 citations
Disentangling general impairment from psychosis-related symptom severity suggests potentially different underlying processes, and developing imaging biomarkers accounting for these processes may guide early detection strategies and targeted interventions.
N. Penzel, K. Cho, J. Seitz-Holland et al.· Molecular Psychiatry· 0 citations
SIB in CHR-P individuals reflects a multidimensional clinical profile primarily outside of core psychosis-risk symptoms, and overall subthreshold psychotic symptoms across the SIB spectrum indicate increasing overall subthreshold psychotic symptoms across the SIB spectrum.
S. Damiani, M. Orlandi, U. Provenzani et al.· Acta Psychiatrica Scandinavi...· 0 citations
Adolescents with distinct longitudinal PLEs and autistic traits trajectories differed on psychopathology, cognitive performance, environmental adversity, and white matter microstructure.
Grace R. Jacobs, S. Cetin-Karayumak, F. Coutts et al.· Biological Psychiatry: Cogni...· 0 citations
The Coupled Stochastic Dynamical System is introduced, a forward generative model that jointly simulates digital engagement, weara-ble physiology, and psychiatric burden as a family of coupled stochastic processes and position generative behaviour-al models as falsifiable and interpretable frameworks for studying youth...
N. Koutsouleris, G. Turner, N. Penzel et al.· medRxiv· 0 citations
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