Author

N. R. G. Silver

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Open access Aug 2026

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Abstract Conformationally distinct “strains” of α‐synuclein aggregates are believed to contribute to the clinical and pathological diversity observed among synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease. Cases of MSA can be classified into two distinct subtypes: the cerebellar variant,...

Heather H. C. Lau, N. R. G. Silver, Surabhi Mehra et al. · Brain Pathology · 0 citations

Open access Aug 2026

Differently sized soluble α-synuclein species from multiple system atrophy and Lewy body disease brains display different seeding propensities

Different conformations, or strains, of α-synuclein (α-syn) aggregates are believed to be responsible for the distinct seeding propensities, propagation profiles, and clinical presentations in Lewy body diseases (LBD) and multiple system atrophy (MSA). While biochemical properties and strain differences of insoluble de...

S. Zampar, Y. Mei, F. Samuel et al. · bioRxiv · 0 citations