Abstract A051: CREB1 integrates EGFR/ERK and p38/LIF oncogenic inputs as a transcriptional convergence hub in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is driven by convergent oncogenic signaling; however, transcriptional regulators that integrate these pathways remain poorly understood. CREB1 is activated via the EGFR/ERK/MSK1 and p38/LIF axes, making it a potential transcriptional convergence node. The CREB1-associated c...