Ebselen sensitizes multidrug-resistant cancer cells to doxorubicin by disrupting cellular redox homeostasis and inducing ferroptosis.
AIM Multidrug resistance (MDR), driven by P-glycoprotein (P-gp/ABCB1)-mediated drug efflux and enhanced antioxidant defenses, remains a major obstacle to effective chemotherapy. This study investigated whether thioredoxin reductase (TrxR) inhibition by ebselen induces ferroptosis, suppresses NRF2/Keap1 signaling and re...