AQbD-Optimised Stability-Indicating Green RP-HPLC Method for Simultaneous Determination of Adapalene and Benzoyl Peroxide in Topical Gel
A tetrahydrofuran-free, stability-indicating reversed-phase HPLC method was developed for simultaneous determination of adapalene and benzoyl peroxide in a commercial topical gel. Analytical Quality by Design (AQbD) was used to define the analytical target profile, identify high-risk chromatographic variables, and eval...