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N. Robertson

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Open access Aug 2026

Genetic subtypes of multiple sclerosis severity are uncoupled from inflammatory lesion burden

Determinants of long-term disability in multiple sclerosis (MS) remain incompletely understood, with clinical course varying greatly among individuals. Recent integrative genetic models have identified genomic clusters associated with divergent disability trajectories. Here, we integrated clinical, genetic, and postmor...

G. Abbadessa, K. Kreft, O. Howell et al. · 0 citations
Open access Sep 2026

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.

Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al. · 0 citations

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