Molecular Architecture and Catalytic Mechanisms of Class D Carbapenemases: Insights into Antibiotic Resistance and Carbapenem Design.
The β-lactam class of antibiotics remains indispensable for treating bacterial infections, yet their effectiveness is increasingly compromised by the emergence of carbapenem-hydrolyzing class D β-lactamases, the principal mechanism of carbapenem resistance in Acinetobacter baumannii and an important contributor to resi...