N. Tailor

Glucose-oxidase-integrated zinc-based metal-organic framework (GOx@ZIF-8) nanoparticles as a dual pH/glucose-responsive insulin delivery system for type 2 diabetes management: Synthesis, characterization, and in vitro/in vivo evaluation.

A dual pH- and glucose-responsive PEG-GOx@ZIF-8-Ins nanoplatform for oral insulin delivery via biomimetic co-precipitation is developed and is a promising oral insulin delivery strategy for T2DM.

FOXM1 as a candidate dosage rheostat and state selector in breast cancer: linking multilevel regulation to adaptive plasticity and therapy resistance

FOXM1, a forkhead-box transcription factor, is consistently overexpressed in breast cancer, particularly in the basal-like and triple-negative subtypes, in which high expression predicts poor survival. We propose, as a falsifiable hypothesis rather than an established mechanism, that FOXM1 may function as a dosage-inte...

Recent Advances in MXene Quantum Dots for Cancer Theranostics and Immunomodulation: Design Principles, Biological Interfaces, and Translational Perspectives

Cancer remains a leading cause of morbidity and mortality worldwide, demanding innovative strategies for diagnosis, therapy, and immune modulation. Advances in nanomedicine have positioned MXene quantum dots (MQDs) as promising multifunctional platforms for cancer theranostics due to their tunable physicochemical pro...

From signals to phenotype: multifactorial drivers of tumor-associated macrophage polarization in oral cavity squamous cell carcinoma: a narrative review.

Engineering smart polymeric lipid nanoparticles for breast cancer: The convergence of AI and medical personalization to enhance efficacy and safety.

Breast Cancer (BC) continues to be a predominant cause of cancer-related death globally, with clinical therapy impeded by off-target toxicity and limited therapeutic windows of traditional chemotherapeutics, especially across various molecular subtypes. This study critically assesses the integration of advanced nanocar...

Cinnamic Acid-based Hybrid Molecules as Multitarget Therapeutic Agents for Cancer, Alzheimer's Disease, and Malaria: A Review.

Molecular hybridization has emerged as a powerful medicinal chemistry approach for address the limitations of conventional single-target therapeutics, particularly in the treatment of complex, multifactorial diseases. This strategy involves integrating two or more pharmacologically active pharmacophores into a single m...

NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities.

The molecular mechanisms by which NRF2 regulates ferroptosis, including KEAP1-NRF2 signaling, metabolic rewiring, iron homeostasis, lipid remodeling, and crosstalk with p53 and other stress-response pathways are summarized.

Gasdermin-mediated pyroptosis as a prognostic biomarker and therapeutic target in hepatocellular carcinoma.

Examination of molecular circuitry linking pyroptosis with inflammasomes, metabolic stress, mitochondrial dysfunction, hypoxia, and epigenetic regulation in HCC suggests regulated pyroptosis may represent a promising immunomodulatory framework for improving precision therapy in HCC.

Multifunctional Therapeutic Potential of Corynoline: A Benzophenanthridine derived Alkaloid.

This review aims to comprehensively summarize current knowledge regarding the chemical characteristics, pharmacological activities, underlying molecular mechanisms, and therapeutic prospects of corynoline to stimulate future research aimed at harnessing corynoline's unique chemical scaffold for the development of innov...

AEG-1/MTDH: A central regulator of tumor progression, metabolic adaptation, and therapeutic resistance in gliomas.

Gen silencing studies demonstrate that AEG-1 knockdown reduces proliferation, promotes apoptosis, and enhances sensitivity to chemotherapeutic agents such as cisplatin, doxorubicin, and temozolomide, and support its potential as a target for combinatorial therapeutic strategies to improve outcomes in aggressive brain a...

Ferroptosis in the Tumor Immune Microenvironment: Mechanisms, Nanomedicine, and Immunotherapy

The regulatory mechanisms linking ferroptosis and the tumor immune microenvironment are highlighted, a critical discussion of recent developments in bionanomaterial‐based therapeutic platforms is provided, and the challenges and prospects for clinical application of these platforms for immunotherapy are outlined.

The CREM–IL-15 axis: decoding the persistence–exhaustion paradox in NK cell immunotherapy

In CAR-NK models, Rafei further demonstrated in CAR-NK models that CREM functions as a regulatory checkpoint limiting NK cell cytotoxicity and cytokine production, while its relevance in resting/native NK cells remains to be established.