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N. Takigawa

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Open access Nov 2026

Plasma metabolomic profiling to predict durable response and survival with afatinib in EGFR-mutated non-small cell lung cancer: A prospective, multicenter, observational biomarker study

While EGFR tyrosine kinase inhibitors (TKIs) like afatinib are standard treatments for EGFR-mutated non-small cell lung cancer (NSCLC), predicting which patients will achieve durable responses remains challenging. Given the emergence of more toxic and costly combination therapies, identifying candidates who can ach...

T. Honda, K. Morikawa, Saori Takata et al. · 0 citations
Open access Aug 2026

Establishment and functional characterization of an EGFR-amplified tumoroid from squamous cell carcinoma of unknown primary

It is demonstrated that a CUP-derived tumoroid can be successfully established while preserving the key molecular and pathological features of the original tumor, and this model provides a platform for functional evaluation of therapeutic vulnerabilities and offers proof-of-concept for integrating patient-derived tumor...

Miki Iwai, Etsuko Yokota, T. Yukawa et al. · 0 citations

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