TRIM41 stabilizes RBPJ through K63 linked ubiquitination and promotes stemness of hepatocellular carcinoma cells.
Persistent activation of the Notch signaling pathway is closely associated with the maintenance of cancer stem cells (CSCs) and the progression of hepatocellular carcinoma (HCC). Recombination signal binding protein for immunoglobulin kappa J region (RBPJ), a key transcription factor that mediates downstream target gen...