N. Van Roy

A functional landscape for chromosome 17q in neuroblastoma: balancing replication stress and genomic stability.

Neuroblastoma is characterised by extensive genomic instability despite a marked paucity of recurrent somatic mutations. Instead, the disease is predominantly driven by chromosomal alterations, including segmental chromosomal imbalances, small structural variants, and oncogene amplification. A major unmet challenge is...