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The prevalence of APOE ε4 allele in SCD falls between that observed in CN and MCI populations, supporting its role as an intermediate stage in the AD continuum, however, substantial heterogeneity persists, highlighting the need for more accurate stratification approaches.
The available case reports highlight marked clinical heterogeneity in carnosinemia, ranging from severe neurodevelopmental phenotypes to asymptomatic biochemical abnormalities, which underscores the need for improved phenotypic characterization, systematic follow-up, and international case registries.
The recent literature highlights a high and increasing prevalence of muscle loss after surgery, driven by reduced protein intake, micronutrient deficiencies, hormonal changes, and decreased mechanical loading.
Frailty components, especially weakness and slowness, are significantly associated with mortality and related outcomes, highlighting the urgency of early frailty detection to improve patient prognosis and urging early identification and intervention to enhance patient care and reduce clinical burden.
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