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It is suggested that cumulative illness burden is a key factor associated with brain structural decline in MDD, while also suggesting potential reversibility in more favorable disease courses.
The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.
This study provides the first data-driven evidence for a potential causal role of gut microbiota in the pathophysiology of depression in humans, and employs state-of-the-art causal inference tools within Judea Pearl's framework.
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