Neurodevelopmental and psychiatric conditions have long been hypothesised to emerge from changes in the structure and function of the brain. However, the molecular and cellular mechanisms linking brain structure to these conditions remain unknown. Here, using genetic and structural/diffusion neuroimaging data from 59,2...
Y. He, A. Ebneabbasi, K. Rademaker et al.· medRxiv· 0 citations
Abstract Background Substance Use Disorders (SUDs) are major contributors to global morbidity and premature mortality. While their adverse physical and psychiatric sequalae are widely attributed to toxic effects of substance exposure, accumulating evidence suggests that inherited liability to addiction also shapes broa...
M. Graczyk, C. Albiñana, A. Lee et al.· International Journal of Neu...· 0 citations
Predicting antidepressant response remains a major challenge, and it is unclear whether reported polygenic associations reflect drug-specific non-response or a broader propensity for treatment modification. We analysed participants with at least one antidepressant monotherapy episode of [≥]28 days in the All of Us (AoU...
A. Walker, X. Wang, J. Bos et al.· medRxiv· 0 citations
These findings establish 24-hour wrist movement as a rich and scalable source of health information, with the potential to support passive health monitoring and disease prediction at population scale, and establish Sensori, a self-supervised foundation model that learns general-purpose health representations directly f...
Yong Wang, D. McGagh, K. Broomberg et al.· 0 citations
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