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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Na Huang

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2 papers indexed here

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Open access Aug 2026

Autocrine PD-1-blocking nanobodies enhance the antitumor efficacy of TCR-like CAR-T cells by attenuating t cell exhaustion

Chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable success in hematologic malignancies, but its efficacy against solid tumors is severely limited by two core barriers: the scarcity of uniformly expressed tumor-associated antigens (TAAs) and the immunosuppressive tumor microenvironment (TME), in wh...

Wan-Jun He, Kai Cui, Yi-Wei Zeng et al. · 0 citations
Open access Jul 2026

Low-dose docetaxel reprograms CAR T cells for enhanced solid tumor immunity.

BACKGROUND Chimeric antigen receptor (CAR) T cell therapy in solid tumors is hampered by dense stromal barriers, rapid functional exhaustion, and limited persistence. Here, we report that low-dose docetaxel acts as an immunomodulatory primer that reprograms CAR T cells to address these barriers. Retrospective analysis...

Songshan Zhu, Jun Yin, Xin Fu et al. · 0 citations

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