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Author

Na Sun

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Open access Sep 2026

Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain.

A single-cell atlas of APA of the aged human brain across 2 million cells from 379 human postmortem brains is reported to provide a cell-type-specific foundation to interrogate the cis and trans regulation of APA and to understand the contribution to disease heritability of this key post-transcriptional layer.

Jiu-Hong Nan, Carles A. Boix, Shao-Hui Shi et al. · 1 citation
Open access Aug 2026

Context-dependent regulatory networks connect Alzheimer’s disease genetics to microglial inflammatory responses

Inflammation is central to Alzheimer’s disease (AD) pathogenesis. Microglia, the resident innate immune cells of the brain, exhibit diverse inflammatory states and are enriched for AD-associated genetic variants within active cis-regulatory elements (CREs). However, the interplay among genetic variants, transcription f...

Ting-Ting Fu, Margareta Kurkela, Jia-Yong Tu et al. · 0 citations

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