Nada A. Khaled

Integrated experimental and computational exploration of 1,8-naphthyridine hydrazones as promising topoisomerase II-targeting anticancer agents

DNA topoisomerase II (Topo II) is essential for maintaining DNA topology during replication, transcription, and chromosome segregation. Its increased expression is associated with tumor progression, which makes it an appealing target for anticancer therapy. However, clinically used Topo II inhibitors such as etoposide...