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Author

Nada Alaaraj

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Review Open access Sep 2026

Adolescent Tobacco and Cannabis Exposure: Effects on Growth, Bone Health, Endocrine Function, and Reversibility: A Critical Narrative Review

Adolescence is a developmentally sensitive interval in which linear growth, pubertal endocrine maturation, body-composition change, and rapid skeletal mineral accrual occur while experimentation with nicotine, tobacco, and cannabis commonly begins. This critical narrative review evaluates whether exposure to combustibl...

Ashraf T. Soliman, F. Alyafei, Nada Alaaraj et al. · 0 citations
Review Oct 2026

Growth plate senescence, chondrocyte biology, and the growth hormone–insulin-like growth factor 1 axis in childhood growth

Abstract Longitudinal bone growth in children depends on endochondral ossification within the epiphyseal growth plate, a process long viewed as a passive readout of systemic hormones but now recognized as an actively regulated, self-limiting process. This mini-review synthesizes recent evidence on chondrocyte biology,...

Ashraf T. Soliman, F. Alyafei, Nada Alaaraj et al. · 0 citations
Review Open access Aug 2026

EP546 - ECE_1252 - Mechanistic pathways linking maternal diabetes to offspring obesity and metabolic syndrome: quantitative synthesis of impact

Quantitative analysis reveals that fetal programming and adipose tissue development are the predominant mechanisms, but endocrine, epigenetic, and environmental factors also play significant roles, and underscore the need for mechanistic-based risk assessments in clinical practice to guide early interventions in at-ris...

Fawziya Alyafei, Ashraf T. Soliman, A. Elawwa et al. · 0 citations
Review Aug 2026

Precision medicine in pediatric growth disorders: Integrating clinical phenotype, genetics, IGF-1 biology and artificial intelligence: A systematic scoping review of PubMed-indexed literature (2000-2026).

This is a systematic review employing narrative synthesis on monogenic and polygenic genetic determinants of pediatric growth faltering and/or short stature and their diagnostic yield to synthesize evidence on artificial intelligence and digital-health tools, bone-age algorithms, facial-recognition phenotyping, adheren...

Ashraf T. Soliman, F. Alyafei, Nada Alaaraj et al. · 0 citations
Review Open access Aug 2026

Genetic Approach in Diagnosis and Follow-Up of Patients with Thalassemia: A Comprehensive Narrative Review

A tiered, genotype-informed approach—combining HPLC/CE phenotyping, targeted molecular diagnostics, genetic modifier profiling, and periodic re-evaluation—optimizes diagnostic precision and guides individualized management across the thalassemia spectrum.

Ashraf T. Soliman, F. Alyafei, Nada Alaaraj et al. · 0 citations

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