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Author

Naeun Kwak

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Open access Jul 2026

Computational protein stability analysis of SCN1A missense variants reveals domain‐dependent stability patterns

Abstract Objective To determine whether computational protein‐stability predictions discriminate pathogenic from benign SCN1A missense variants, and to characterize the structural distribution of predicted destabilization among pathogenic variants. Methods On an AlphaFold3‐predicted Nav1.1 structure, FoldX, and Rosetta...

Y. Shim, E. Kang, Naeun Kwak et al. · 0 citations

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