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Author

Nafeesa Naeem

3 papers indexed here

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Open access Aug 2026

Discovery of 4-aminochalcone-based dual α-glucosidase and aldose reductase inhibitors: in vitro, in vivo, and in silico studies

Diabetes mellitus is a chronic metabolic disorder associated with persistent hyperglycemia and the development of numerous secondary complications. In the present study, a series of 4-aminochalcone derivatives (1N–10N) were synthesized and evaluated as potential dual inhibitors of α-glucosidase and aldose reductase usi...

E. Mughal, Nafeesa Naeem, Songül Bayrak et al. · 0 citations
Aug 2026

Synthesis and multimodal characterization of flavonols: electrochemical, spectroscopic, and DFT approaches.

Five flavonols bearing electron-donating and electron-withdrawing substituents were synthesized and characterized by NMR spectroscopy, mass spectrometry, UV-Vis spectroscopy, and cyclic voltammetry. Density functional theory (DFT) and time-dependent DFT (TDDFT) calculations were performed to investigate their molecular...

Nafeesa Naeem, Ngs Mateyise, Charlene Marais et al. · 0 citations
Jul 2026

Exploring chalcone-based azo dyes as potential carbonic anhydrase-I/II inhibitors through experimental and computational studies.

It is demonstrated that azo-chalcone hybrids constitute a promising scaffold for the development of potent carbonic anhydrase inhibitors, with compound 1 identified as a strong candidate for further optimization and preclinical investigation.

E. Mughal, Nafeesa Naeem, Ishtiaq Ahmed et al. · 0 citations

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