Sep 2026
Losartan inhibits methotrexate-induced testicular damage via anti-inflammatory and anti-apoptotic effects.
It is demonstrated that AT1R inhibition using Losartan successfully mitigates MTX-induced testicular damage by addressing this upstream mechanistic pathway and Losartan has been identified as a viable treatment strategy for preserving male reproductive function following cytotoxic therapy.
Somayeh Mohammadi Panah, M. Khezri, Hojat Ghasemnejad-Berenji et al.
· Immunopharmacology and immun... · 0 citations