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Author

Nan Cao

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Open access Jan 2026

A Self‐Assembling β‐Annulus Nanoparticle Vaccine Incorporating OX40L Confers Partial Protection Against NADC30‐Like PRRSV in Piglets

Porcine reproductive and respiratory syndrome (PRRS) remains one of the most economically significant viral diseases affecting the global swine industry, and currently available commercial vaccines provide only limited protection against circulating PRRS virus (PRRSV) strains. Therefore, alternative vaccination strateg...

Lin-Xing Tian, Zheng-Dan Lin, Jia-Hui Ma et al. · 0 citations
Sep 2026

Mosaic Nanoparticles Based on Porcine Ferritin Induces Potent Protective Immunity in Pigs against Serotype O FMDV

The serotypes and subtypes of foot-and-mouth disease virus (FMDV) are highly diverse, making the research and development of cross-protective and high-efficiency foot-and-mouth disease (FMD) vaccines increasingly urgent. In this study, we designed and constructed two mosaic nanoparticles by fusing porcine Ferritin (p...

Nan Cao, Ya-Mei Li, Xing-Hua Chen et al. · 0 citations
Open access Jan 2026

Adaptive Evolution of Serotype O Foot‐and‐Mouth Disease Virus Under Vaccine Pressure: Combined VP1 T142/Q153 Mutations Drive Antigenic Alteration and Immune Evasion

Combined mutations at VP1 142 and 153 reshape viral antigenicity and act as core drivers of FMDV immune evasion, offering an experimental basis for clarifying FMDV evolution and developing broad‐spectrum vaccines.

Nan Cao, Ya-Mei Li, Xing-Hua Chen et al. · 0 citations

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