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Nan-Ding Yu

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Open access Sep 2026

KLF5-driven G6PD protects lung squamous cell carcinoma from ferroptosis by sustaining mitochondrial homeostasis and SLC7A11-dependent cystine uptake.

A KLF5-G6PD-SLC7A11 axis is identified as a critical metabolic safeguard against ferroptosis in LUSC, and targeting G6PD disrupts mitochondrial homeostasis, enhances mitophagy-dependent oxidative stress, and sensitizes tumors to ferroptotic therapy, highlighting a promising therapeutic strategy for LUSC.

Nan-Ding Yu, Ying-Xiao Wu, Meng-Ling Li et al. · 0 citations

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